| Team | # Games | Home | Away | Opponents |
| Braves | 6 | 3 | 3 | at WSH (3), vs. MIA (3) |
| Marlins | 5 | 2 | 3 | vs. OAK (2), at ATL (3) |
| Mets | 7 | 7 | 0 | vs. CHC (3), vs. WSH (4) |
| Phillies | 7 | 5 | 2 | at BOS (2), vs. BOS (2), vs. ARI (3) |
| Nationals | 7 | 3 | 4 | vs. ATL (3), at NYM (4) |
| Cubs | 6 | 0 | 6 | at NYM (3), at PIT (3) |
| Reds | 6 | 3 | 3 | at SD (3), vs. LAD (3) |
| Brewers | 7 | 3 | 4 | at STL (4), vs. SD (3) |
| Pirates | 6 | 6 | 0 | vs. COL (3), vs. CHC (3) |
| Cardinals | 7 | 4 | 3 | vs. MIL (4), at BAL (3) |
| Diamondbacks | 5 | 0 | 5 | at DET (2), at PHI (3) |
| Rockies | 7 | 4 | 3 | at PIT (3), vs. SF (4) |
| Dodgers | 6 | 0 | 6 | at CLE (3), at CIN (3) |
| Padres | 6 | 3 | 3 | vs. CIN (3), at MIL (3) |
| Giants | 6 | 2 | 4 | vs. KC (2), at COL (4) |
| Orioles | 7 | 4 | 3 | at CHW (4), vs. STL (3) |
| Red Sox | 7 | 2 | 5 | vs. PHI (2), at PHI (2), at HOU (3) |
| Yankees | 7 | 0 | 7 | at LAA (3), at OAK (4) |
| Rays | 6 | 0 | 6 | at TOR (2), at DET (4) |
| Blue Jays | 5 | 5 | 0 | vs. TB (2), vs. CHW (3) |
| White Sox | 7 | 4 | 3 | vs. BAL (4), at TOR (3) |
| Indians | 7 | 3 | 4 | vs. LAD (3), at MIN (4) |
| Tigers | 6 | 6 | 0 | vs. ARI (2), vs. TB (4) |
| Royals | 6 | 0 | 6 | at SF (2), at LAA (4) |
| Twins | 8 | 8 | 0 | vs. SEA (4), vs. CLE (4) |
| Astros | 6 | 6 | 0 | vs. TEX (3), vs. BOS (3) |
| Angels | 7 | 7 | 0 | vs. NYY (3), vs. KC (4) |
| Athletics | 6 | 4 | 2 | at MIA (2), vs. NYY (4) |
| Mariners | 7 | 0 | 7 | at MIN (4), at TEX (3) |
| Rangers | 6 | 3 | 3 | at HOU (3), vs. SEA (3) |
- The Marlins, Diamondbacks, and Blue Jays all have 5 games this week. The Diamondbacks are hurt most by this scheduling as all 5 of their games are on the road away from Chase Field, arguably the most hitter-friendly ballpark.
- The Twins have 8 games next week, all in Minneapolis at Target Field. The Twins home ballpark is 5th in terms of ballpark factors for runs, and 7th for home runs so this is could be a strong offensive homestand for the Twinkies.
- The Baby Bombers go out on a west coast road trip to face the Angels and Oakland. Despite leaving the offensive-friendly confines of Yankee Stadium, both the Athletics and Angels still hit in very productive ballparks for hitters so this isn’t necessarily a downgrade for New York.
| AWAY TEAM | HOME TEAM | # GAMES | DH? | PLAYER(S) IMPACTED |
| Athletics | Marlins | 2 | NO | Ryon Healy, Trevor Plouffe |
| Phillies | Red Sox | 2 | YES | Howie Kendrick |
| Red Sox | Phillies | 2 | NO | Mitch Moreland, Hanley Ramirez |
| Diamondbacks | Tigers | 2 | YES | Chris Herrmann, Chris Iannetta |
| Dodgers | Indians | 3 | YES | Adrian Gonzalez |
| Royals | Giants | 2 | NO | Brandon Moss |
- There are a few interleague matchups in week 11. Ryon Healy likely won’t be impacted by the lack of a DH spot in Miami. Oakland could use a day to rest him or find a spot for him in the field. However, when the Red Sox travel to Philly and lose the DH Mitch Moreland and Hanley Ramirez could possibly trade off first base duties during the short two-game series.
| Rank | Pitcher | Matchup #1 | Matchup #2 |
| 1 | Clayton Kershaw (LAD) | at CLE | at CIN |
| 2 | Stephen Strasburg (WSH) | vs. ATL | at NYM |
| 3 | Chris Sale (BOS) | at PHI | |
| 4 | Max Scherzer (WSH) | at NYM | |
| 5 | Jake Arrieta (CHC) | at PIT | |
| 6 | Lance McCullers Jr. (HOU) | vs. TEX | |
| 7 | Corey Kluber (CLE) | vs. LAD | |
| 8 | Carlos Carrasco (CLE) | at MIN | |
| 9 | Jacob deGrom (NYM) | vs. CHC | vs. WSH |
| 10 | Chris Archer | at DET | |
| 11 | Yu Darvish (TEX) | at HOU | vs. SEA |
| 12 | Robbie Ray (ARI) | at PHI | |
| 13 | Carlos Martinez (STL) | vs. MIL | |
| 14 | Justin Verlander (DET) | vs. TB | |
| 15 | Zack Greinke (ARI) | at DET | |
| 16 | David Price (BOS) | vs. PHI | at HOU |
| 17 | Kyle Hendricks (CHC) | at PIT | |
| 18 | Jon Lester (CHC) | at NYM | |
| 19 | Alex Wood (LAD) | at CIN | |
| 20 | Rich Hill (LAD) | at CLE | |
| 21 | Johnny Cueto (SF) | vs. KC | |
| 22 | Alex Meyer (LAA) | vs. NYY | vs. KC |
| 23 | Lance Lynn (STL) | vs. MIL | at BAL |
| 24 | James Paxton (SEA) | at TEX | |
| 25 | Tyson Ross (TEX) | vs. SEA | |
| 26 | Luis Severino (NYY) | at OAK | |
| 27 | Sean Manaea (OAK) | vs. NYY | |
| 28 | Junior Guerra (MIL) | vs. SD | |
| 29 | Michael Pineda (NYY) | at LAA | at OAK |
| 30 | Marco Estrada (TOR) | vs. TB | |
| 31 | Steven Matz | vs. WSH | |
| 32 | John Lackey (CHC) | at NYM | at PIT |
| 33 | Drew Pomeranz (BOS) | at HOU | |
| 34 | Joe Ross (WSH) | vs. ATL | at NYM |
| 35 | CC Sabathia (NYY) | at LAA | at OAK |
| 36 | Brad Peacock (HOU) | vs. TEX | |
| 37 | Masahiro Tanaka (NYY) | at OAK | |
| 38 | Aaron Nola (PHI) | vs. ARI | |
| 39 | Jordan Montgomery (NYY) | at LAA | |
| 40 | Jason Vargas (KC) | at SF | at LAA |
| 41 | Trevor Bauer (CLE) | vs. LAD | at MIN |
| 42 | Andrew Triggs (OAK) | at MIA | |
| 43 | Jimmy Nelson (MIL) | at STL | vs. SD |
| 44 | Buck Farmer (DET) | vs. ARI | vs. TB |
| 45 | Brandon McCarthy (LAD) | at CLE | |
| 46 | Joe Biagini (TOR) | vs. CWS | |
| 47 | Jharel Cotton (OAK) | at MIA | vs. NYY |
| 48 | Jason Hammel (KC) | at SF | |
| 49 | Matt Shoemaker (LAA) | vs. NYY | |
| 50 | Ervin Santana (MIN) | vs. SEA |
- Clayton Kershaw edges out Stephen Strasburg as the top starting option in week 11. Kershaw has some tough road matchups against Cleveland and Cincinnati, but considering his elite-pitching prowess he’s the top option in a two-start week.
- Pineda almost fell outside the Top 30 largely because his home/road splits are so drastic. He boasts a 5.96 ERA on the road while opponents are hitting .302/.362/.567 against him. At Yankee Stadium he carries a 1.96 ERA while opposing hitters slash just .191/.232/.315 against the 28-year-old righty.
- Ervin Santana, fresh off an efficient 91-pitch complete game gets a tough home matchup in hitter-friendly Target Field against the hard-hitting Mariners. He still cracks the Top 50 largely because Seattle’s offense isn’t as good on the road, but they still pose a bit of a threat.
| Rank | Pitcher | Matchup #1 | Matchup #2 |
| 51 | J.A. Happ (TOR) | vs. CWS | |
| 52 | Marcus Stroman (TOR) | vs. CWS | |
| 53 | Jaime Garcia (ATL) | vs. MIA | |
| 54 | Sonny Gray (OAK) | vs. NYY | |
| 55 | Brian Johnson (BOS) | at PHI | |
| 56 | Michael Wacha (STL) | vs. MIL | |
| 57 | Michael Fulmer (DET) | vs. ARI | |
| 58 | Zack Wheeler (NYM) | vs. CHC | vs. WSH |
| 59 | Chase Anderson (MIL) | vs. SD | |
| 60 | Matt Harvey (NYM) | vs. CHC | |
| 61 | Dan Straily (ATL) | at ATL | |
| 62 | Gerrit Cole (PIT) | vs. COL | |
| 63 | Edinson Volquez (MIA) | vs. OAK | |
| 64 | Francisco Liriano (TOR) | vs. TB | |
| 65 | Ariel Miranda (SEA) | at MIN | |
| 66 | Scott Feldman (CIN) | at SD | |
| 67 | Ian Kennedy (KC) | at LAA | |
| 68 | Gio Gonzalez (WSH) | at NYM | |
| 69 | Jeff Samardzija (SF) | at COL | |
| 70 | Dinelson Lamet (SD) | at MIL | |
| 71 | Rick Porcello (BOS) | vs. PHI | at HOU |
| 72 | Randall Delgado (ARI) | at PHI | |
| 73 | Sean Newcomb (ATL) | vs. MIA | |
| 74 | Dylan Bundy (BAL) | at CWS | |
| 75 | Tyler Chatwood (COL) | at PIT | vs. SF |
- Tyler Chatwood cracked the bottom of the secondary pitching group with a road start in Pittsburgh and a home start against one of the worst offenses in baseball, the San Francisco Giants. He’s done well enough in his last two starts to earn consideration as a two-start pitcher in week 11.